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Immunohistochemical analysis also revealed a significant decrease in the hepatic expression of both proapoptotic markers Bax and caspase-3 with significant increase in antiapoptotic Bcl-2 expression in rats treated with NTZ-200, NAC or 4-PBA when compared to MTX group (Figure 9)

During the healing process, damaged tissues experience increased oxidative stress, which can hinder recovery

Psychiatry , 51 (3), 241249

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However, a limitation of that study was that the number of subjects considered was very small [130]