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Research on GLP-1 Use in People With Bipolar Disorder Is Limited The original randomized, controlled trials for GLP-1s often didnt include participants with bipolar disorder, notes the nonprofit International Bipolar Foundation

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A systematic review of drug-drug interactions with GLP-1RAs found that most co-administered oral drugs did not experience clinically significant changes in total exposure (AUC), although reduced peak concentrations (Cmax) and delayed time to peak (Tmax) were commonly observed, particularly for drugs with high solubility and permeability (108)

The comments and suggestions provided by the anonymous reviewers significantly improved this manuscript and we greatly appreciate their efforts