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Previous studies have demonstrated that the aqueous humor of glaucoma patients shows alterations in the levels of certain proteins, such as those that contribute to oxidative damage, mitochondrial damage, neural degeneration, apoptosis, immune responses, and the complement cascade 19,20,21,22

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require documentation of indication, dosing, and clinical response Biologics (IL-12/23 inhibitor): Ustekinumab (Stelara, J3357) FDA-approved for moderate-to-severe CD

Biometrika 96 , 187199 (2009)