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A patient at BMI 32 with no severe comorbidities may achieve their health goals at 2022% weight loss

Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

If changes emerge shortly after starting the medication or increasing the dose and improve when the dose is reduced that suggests the medication may be contributing

Why it matters: Butyrate improves gutbrain communication, which is deeply tied to sleep regulation and mood

There's also a lot of stigma and misinformation and misunderstanding around it

Weekly check-ins keep you motivated and accountable