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Together, these studies reinforce a clear effect on the gutbrain axis: metformin activates AMPK in enteroendocrine cells, restoring their ability to sense nutrient status and secrete hormones that shift metabolism in a positive direction

This action decreases the amount of glucose entering your bloodstream from the food you consume

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The mesolimbic system is very much wired to listen to GLP-1, Skibicka says

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