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10.1186/s12987-019-0139-4 75 KebirH.IferganI.AlvarezJ

By inhibiting NNMT, 5-Amino-1MQ increases cellular SAM and NAD+ levels, enhances NAD+ salvage pathway flux, activates SIRT-1, boosts oxidative phosphorylation (OXPHOS), and influences cellular energy homeostasis and epigenetic modifications

The established maximum doses represent the upper limits studied in clinical trials, beyond which risk-benefit ratios become unfavorable

10 : e0133622