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In cases where metformin is not suitable or not sufficient to achieve target blood glucose levels, healthcare providers may consider adding or switching to other medications, such as GLP-1s, DPP-4 inhibitors, SGLT-2 inhibitors, or insulin

Adapted from: Ast J, Novak AN et al

If you choose a loading phase, 20 g daily divided into four 5 g doses for 57 days, followed by 35 g maintenance, works but increases water retention

While this practice is legal and sometimes necessary due to drug shortages, it requires additional scrutiny: A significant concern among patients is potential medication dilution or quality issues

Your first weeks decide your long-term success

In parallel, we visualized meiotic entry with DAPI staining