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GLP-1 Agonists (Semaglutide, Tirzepatide) These compounds have FDA-approved versions (Ozempic, Mounjaro) with extensive safety and efficacy data from large clinical trials

This includes blood tests for common parameters: 25-OH-vitamin D, vitamin B12 (plus holotranscobalamin), whole blood magnesium, zinc and selenium in whole blood/serum, if necessary

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Insomnia and sleep disturbances are not listed among the common adverse reactions for tirzepatide in the FDA-approved prescribing information for either Mounjaro or Zepbound

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Weeks 3 to 6: Introduce strength and fiber goals Add a strength training plan 2 to 4 times per week, starting at a manageable level and gradually increasing intensity