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Mass Spectrometry Identity Confirmation Lot identity is verified by LC-MS, with the observed mass matched against the theoretical 401.91 g/mol value for the CHCuNO complex

Cell Death Dis 17 , 325 (2026)

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

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Vegetarians and vegans : B12 is found predominantly in animal products, so individuals following plant-based diets may be at risk of deficiency