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Emerging preclinical and clinical evidence suggests these medications may modulate reward-seeking behaviour and reduce the reinforcing effects of alcohol, though this remains an area of active investigation rather than established clinical practice

Those symptoms include vaginal dryness, decreased lubrication during arousal, hot flashes, mood changes, and reduced sexual desire

Walking deserves a mention too

Found in eggs, nuts, seeds

And in animal models, glucagon activates brown fat thermogenesis, essentially turning up the body metabolic furnace to burn more calories as heat

The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%