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Even trace amounts of metal ions from the rubber stopper or glass vial can catalyze oxidation reactions over time

Glutathione is made from the sulfur-containing amino acid cysteine

SOD and catalase activities were higher in the VC + VE group on day 1, indicating that supplemented antioxidants upregulated the antioxidant enzymes

In summary, despite many studies indicating the oral administration of vitamin B12 to be easy, effective and less costly than intramuscular administration, their designs, and in some cases their methodological limitations, mean that debate still surrounds the effectiveness of the oral route

Hepatology 66 (Suppl