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Comparable data-driven phenotyping in cirrhosis and ACLF has repeatedly highlighted inflammation-rich clusters with both high short-term mortality and high potential for rapid improvement when reversibility is present (Laleman et al., 2018)

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Moreover, the redox-sensitive Keap1-Nrf2 pathway is activated in nucleated cells following oxidative stress to provide an adaptive and protective response by antioxidant enzymes upregulation [215], which is not possible in mature erythrocytes