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Patients with Renal Impairment Dapagliflozin At steady-state (20 mg once daily dapagliflozin for 7 days), adult patients with type 2 diabetes mellitus with mild, moderate, or severe renal impairment (as determined by eGFR) had geometric mean systemic exposures of dapagliflozin that were 45%, 100% and 200% higher, respectively, as compared to patients with type 2 diabetes mellitus with normal renal function
doi: 10.3389/fcell.2021.703218 156 YangJCZhaoMChernikovaDArias-JayoNZhouYSituJet al
[1] [2] Severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with underlying renal impairment
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