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They were also pressing on my internal organs, causing my kidneys to swell, and I became incontinent because they were pressing on my bladder, and I could not empty the bladder

In fact, The American Board of Obesity Medicine (ABOM) came together just 15 years ago (in 2011)

Zanni S, Cammalleri V, DAgostino L, Protano C, Vitali M

Consumers in environments with high oversight may not value the extra protections if they expect identical products

develop clinical guidelines for identifying drug-induced neurological effects

Anyway, at higher concentrations, like those deriving from a high-fat diet, primary and secondary BAs can reduce gut barrier integrity with their detergent properties, causing increased intestinal permeability and, thus, oxidative stress, DNA damage, and production of inflammatory cytokines, such as IL-6 and TNF-alpha, which promote inflammation and cause the inactivation of the FXR, thereby powering a pro-inflammatory state in the colon [25]