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However, because of the preliminary nature of these studies, the overall rating was C due to limited evidence, although one double-blind placebo-controlled study using NAC in human lead exposure was promising

Daily intake from diet generally averages 0.52 g/day

Metabolism produces active metabolites (notably M1), which contribute to the prolonged effect without a pronounced spike

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doi: 10.1371/journal.pone.0006031 62 MichalekRDGerrietsVAJacobsSRMacintyreANMacIverNJMasonEFet al