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This savings becomes significant over the course of a 48-week or longer treatment protocol

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At 6 months multivariate analysis demonstrated no significant difference between groups (2.0 kg, 95%CI:4.2, 8.1 kg, p = 0.50, Supplementary Table 6.2)

Repeated, sustainable food changes that increase fermentable substrates in the colon and ensure regular protein at meals can change microbial fermentation patterns and modestly increase GLP-1 over weeks to months, leading to more consistent satiety for many people, though results vary by individual microbiome