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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

Comparative work with tirzepatide further isolates the specific contribution of glucagon receptor agonism to the overall pharmacological profile

The Vote and What It Means Despite internal objections from agency scientists, the PCAC voted 8-6 in favor of recommending BPC-157 for inclusion, specifically for use in treating ulcerative colitis

This is the most frequently reported effect and typically resolves within minutes to hours

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H.GilskiM.ChangC.BorekD.RosenbaumG.LavensA.et al (2024)