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2 The new generation of obesity management medications, glucagon-like peptide-1 (GLP-1) receptor agonists liraglutide (Saxenda) and semaglutide (Wegovy), as well as dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor agonist tirzepatide (Zepbound), have demonstrated unprecedented efficacy in weight reduction, averaging 15% to 25% total body weight loss

In most cases, medications that require compounding are sent to pharmacies that specialize in this service

Significant joint pain, persistent numbness or tingling, or notable changes in blood glucose warrant reassessment

For people prioritizing cardiovascular safety, semaglutide currently has the strongest evidence base, with two completed cardiovascular outcomes trials showing clear benefit

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