Giannoulis MG, Sonsken PH, Umpleby M, Breen L, Pentecost C, Whyte M, McMillan CV, Bradley C, Martin FC
GLP-1 and GIP: The Incretin Synergy Tirzepatide is the first medication to act as a dual agonist of: Glucagon-like peptide-1 (GLP-1) receptor Glucose-dependent insulinotropic polypeptide (GIP) receptor These two hormones are part of the incretin system, a group of gut-derived peptides released in response to food intake
Each compound was also incubated in the absence of pancreatin (8.3 L of the oligomer stock solution was diluted with 190 L of TRIS 10 mM pH 7.5)
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Li, W., Li, Z., Yang, J
Liu BD, et al