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Although ECL3 of the ligand-free GLP-1R swings out of the peptide-binding pocket, the extracellular portion of TMD is maintained in a conformation close to the active state, because several residues located at the orthosteric site form an interaction network to stabilize the TMD core

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Ben Othman R, Ben Amor N, Mahjoub F, Berriche O, El Ghali C, Gamoudi A, Jamoussi H

For MACE-4, the HR was 0.80 (95% CI, 0.571.11) for tirzepatide versus standard therapy, the HR for cardiovascular death 0.90 (95% CI, 0.501.61) and 0.80 (95% CI, 0.511.25) for all-cause death