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The nausea results from GLP-1 receptor activation in both the gut (slowing gastric emptying) and the brainstem (activating the area postrema)

Our 2030 estimates contemplate global penetration into the addressable type 2 diabetes and obesity markets of only 8% and 2%, respectively (from about 3% and 0.2% in 2023). Uptake would likely be greater if these drugs could be consumed in oral form rather than injected, adds the report, An oral weight loss agent would likely be well-received in the primary care setting and could alleviate pressure on supply chains

Sleep Dysfunction and Gastrointestinal Diseases

Still, the cost of these drugs can be more than $1,000 per month, although many people pay about half that amount or less through discounts from pharmaceutical companies such as Eli Lilly, and programs from online providers such as Hers for Womens Health and Noom, which offer access to less expensive compounded versions of the drugs

So what kind of consumer should makers of alt GLP-1 receptor agonists be targeting

Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE