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Despite their utility, a significant challenge in iHLO research lies in determining the optimal developmental timepoints for liver-like functionality, which is critical for their effective use in pharmacological and toxicological studies

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Using data from and integrating advanced imaging, proteomics, metabolomics, genetic analyses, and aging clocks, they explored , ,

water-insoluble fillers: talc, calcium carbonate, barium sulfate, or ethylcellulose), mucoadhesive agents (starch, chitosan, gelatin, starch, cellulose derivatives), solubilizers, permeation and absorption enhancers (cyclodextrins, fatty acids, phospholipids, surfactants, bile salts, chelating agents) for better therapeutic efficacy [13,14,32,33,34,35,36]