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Tracy Norfleet, MD, FACP, advises: "Injection site may be infected if you notice redness, warmth, or tenderness or swelling in the area, and it keeps getting worse or lasts more than 1 to 2 days." Here are specific signs that should prompt you to consult your doctor: Pus or discharge coming from the injection site Warmth spreading beyond the immediate area Red streaking extending outward from the injection site Redness or swelling larger than 2 inches in diameter Hardened lumps that dont go away, suggesting a possible infection Severe pain that disrupts your daily activities Reactions lasting more than a week Unusual skin discoloration Fever accompanied by chills New lumps or swelling in your neck, especially with hoarseness or difficulty swallowing If any of these symptoms appear, dont delay contacting your healthcare provider

This rule is waived if youre more than 30 miles away from a Kaiser pharmacy, and it only affects those on the Choice PPO plan

She was on a DMARD and a biologic both at full doses and still having multiple flares per month

After implementing some of these strategieseating smaller, more frequent meals, avoiding high-fat foods, and using a short course of anti-nausea medication during dose increasesthey found their nausea became much more manageable

Even among those that don't report significant clinical side effects, the financial burden of these drugs, as well as the injectable nature of the most popular versions (which much be administered via subcutaneous injection), are major deterrents for many patients

If you've never self-injected before, ask your provider about administration technique and what to expect during your initial consultation