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11 The pathophysiologic mechanisms in TS include disruption of GABA conduction, leading to impaired inhibition within the cortical-basal ganglia loop
Participants either followed an exclusion diet, defined as gluten and casein free regimen adopted independently by families before enrolment, or an unrestricted die, an important source of baseline heterogeneity, as dietary patterns were not experimentally assigned
Other factors, such as vascular comorbidities, male sex, and rapid changes in glucose and blood pressure (especially nocturnal dips), may predispose to NAION [44]