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This hypothesis was investigated by Grigg et al

This comprehensive analysis, drawing on research published between 2000 and 2025, identifies key oxidative stress biomarkers, including malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8-OHdG), and total antioxidant capacity (TAC), as valuable tools for assessing sperm health and diagnosing oxidative imbalance

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10.1371/journal.pone.0033172 10 Brigelius-FlohR.KippA

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Going forward, future research should address the following gaps that need to be filled