Although randomized trials of GLP-1RA have demonstrated a meaningful outcome in weight change and other physiological aspects, GLP-1RAs are known to cause gastrointestinal disturbances, and they have been shown to negatively impact the adherence and persistence of their action when discontinued
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This effect may be due to lowered inflammation, reduced body fat, or something else entirely
In this retrospective cohort study, the TriNetX platform inherently manages missing data and patient follow-up based on the practices of contributing healthcare organizations
Cagrilintide complements GLP-1 agonists by targeting distinct satiety pathways through amylin and calcitonin receptors
PMC 2593804
