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Concomitant use of NAC or lipoic acid are best reserved until the patient tolerates the full chelator dose, and the metal quantities being excreted have fallen substantially (e.g., to a quarter or fifth of the initial levels)

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J Pin Res 61(3):396407 Ramos E, Egea J, Lpez-Muoz F, Gil-Martn E, Romero A (2023) Therapeutic potential of melatonin counteracting chemotherapy-induced toxicity in breast cancer patients: a systematic review