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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload

Figure 1 Across human populations, basal G6PD enzyme activity is highly variable, with hundreds of missense genetic mutations described worldwide in the X-linked G6PD gene

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However, a dose of 0.5 mg/kg Nano-Lut was found to be more effective in its antioxidant action than Nano-Bc, as shown by the results of the oxidative stress parameters

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