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To verify DASPEI scores, fish from the same treatment groups were fixed and immunohistochemically processed with anti-parvalbumin (Millipore) to visualize hair cells (see Coffin et al., 3).These results indicate that Dihexa only modulates targets responsible for the acute phase of aminoglycoside ototoxicity

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Subsequently, it inhibited cell proliferation, promoted G0/G1 phase arrest and mitochondrial-dependent apoptosis via ERK1/2

2 Two alternatively spliced forms of the insulin receptor (IR) may form two homodimeric I-Ra and I-Rb receptors or a number of heterodimer receptors combining the I-R and IGF-1R receptor subunits (IGF-1R/I-R)