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Ive got to do that because otherwise I somehow cheated myself, Winfrey said in September 2023 during a panel on Oprah Daily, called The State of Weight. It was after that discussion that she changed her mind about using a weight-loss drug, Winfrey told People, calling it her "biggest aha" moment: I realized Id been blaming myself all these years for being overweight, and I have a predisposition that no amount of willpower is going to control. Frustration with her weight has occupied five decades of space" in her brain, she noted

Albert Bourla, Chairman and Chief Executive Officer at Pfizer, said: Obesity is a large and growing space with over 200 health conditions associated with it

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