If you aren't losing weight on topiramate, your dose may be too low or you may be a clinical "non-responder"
The median follow-up time was 22 months
Starting low and increasing slowly is the single most effective strategy for minimizing GI side effects
What Is the Regulatory Status of Each
Mohammad Al Darawsha MD Jun 12, 2025 3 min read Have you ever felt a pins and needles sensation in your hands, feet, or face
The discovery of the G-proteincoupled estrogen receptor (GPER1) in the early 2000s provided insight into these non-genomic mechanisms ( in vivo role of GPER1 remains under debate ( Ligand-independent actions of estrogen receptors (ERs) have also been described, particularly in the uterus, where ER can be activated by growth factor pathways (e.g., IGF-1), leading to receptor recruitment to chromatin in the absence of estrogen binding (Figure 1)