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It stimulates the pulsatile secretion of endogenous GH by the pituitary gland, which in turn activates downstream hepatic production of IGF-1

In fact, clinical trials show that these medications work best in conjunction with education on eating and exercise

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The Veteran Affairs-Diabetes in Nephropathy Study (VA-NEPHRON-D) and Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (ALTITUDE) trials similarly assessed combination RAAS blockade but were discontinued early due to increased rates of hyperkalemia, AKI, and hypotension [88,89]

Stevens, F.G