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Metabolism & aging (preclinical): NAD+-dependent sirtuin and PARP activity has been linked to DNA repair and metabolic regulation in animal models [11]
Initially overlooked due to technical constraints, their significance became apparent with the identification of lin-4 and let-7, which regulate developmental timing in Caenorhabditis elegans by binding imperfectly to the 3 UTRs of target mRNAs
Frequency : IV injection in preclinical models Duration : Acute and short-term dosing in fibrosis models Published in Nature Communications (2022)
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