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Sirtuins, including SIRT3, play a central role by deacetylating key proteins in the electron transport chain, cyclophilin D of the mitochondrial permeability transition pore (MPTP), and antioxidant enzymes such as superoxide dismutase 2 (SOD2) [36, 37]

The accumulation of transcripts of Alu RNA in geographic AMD was caused due to dysregulation in DICER1

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Direct evidence for DMT1-mediated Mn transport is lacking, with only indirect evidence from an early study (Erikson and Aschner, 2006)

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