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We believe the magnitude of weight loss, robust reductions in triglycerides, LDL (low-density lipoprotein) cholesterol and blood pressure, together with the safety profile observed in this trial, could potentially differentiate pemvidutide from the other incretin-based therapies, said Vipin K

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Kner, P., Sedat, J

However, according to the Ozempic SmPC, clinical studies have not demonstrated significant reductions in the efficacy of commonly tested medications

So people had decided they had lost enough or too much and they were done. Basically, if weight loss is your main health goal, you may find retatrutide works a little too well, and a less powerful drug or lifestyle changes may be better for you