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In individuals with overweight or obesity and type 2 diabetes, semaglutide 2.4 mg resulted in a mean weight loss of 9.6% compared to 3.4% with placebo in 68 weeks

In PTC, high PGRN expression facilitates cell proliferation, accelerates cell cycle transition, inhibits apoptosis and drives metastasis by activating the JAK2-STAT3/4 signalling pathway [141]

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In PIONEER 3, comparisons of semaglutide to sitagliptin demonstrated non-inferiority in A1C (%) reduction at week 26 for the 7 mg and 14 mg dosage strengths

FLOW was the only trial listed with a primary kidney outcome, specifically designed to assess the effect of a GLP-1 receptor agonist on major kidney events

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