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doi: 10.1016/j.pharmthera.2021.107916 216 Prez de la LastraJ

Retatrutide also improved insulin sensitivity and glucose metabolism beyond what youd expect from weight loss alone, suggesting direct receptor-mediated effects on metabolic tissues

Amylin is colocated with insulin in secretory granules and cosecreted with insulin by pancreatic beta cells in response to food intake

GLP-1 plays a role in insulin release and blood sugar regulation and also interacts with areas of the brain involved in appetite signaling