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Additionally, if youre living with obesity and struggling to lose weight, GLP-1s effectively support clinically significant weight loss of more than 10% of body weight

Specifically, beyond the enteroendocrine L-cells of the intestine, GLP-1 is also produced as a neuropeptide by the pre-proglucagon neurons in the brain stem 3

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However, GLP-1(2836) did not affect mitochondrial glucose oxidation in caSMCs cultured in high-glucose medium (Supplemental Figure 12A)

These prescription weight loss drugs are especially effective for people who have struggled to lose weight through diet and exercise alone and need additional medical support

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