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In some embodiments, the otic formulation or composition comprises between about 0.001% to about 20% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

8 Peptide handling guidanceReconstitution and cold-chain storage practices for lyophilized research peptides

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2022 Apr 14;23(8):4334

Trial design Forty-eight healthy participants (79% male, median age: 49 years, BMI: 29.9 kg/m2, body weight: 92 kg) were randomized (3:1) within three cohorts