These figures come from reference protocols, not from approved human dosing the combination itself is not clinically validated
First, the lack of a placebo-controlled and double-blind design may have introduced expectation bias, particularly given the subjective nature of symptom evaluation in BMS
Chang L, Munsaka SM, Kraft-Terry S, Ernst T
Second, brain-mediated autonomic effects are exactly the kind of physiology that is subject to adaptation and counter-regulation over time, which is the mechanistic basis for the tachyphylaxis concern examined below
Some individuals may struggle to absorb enough B12 from their diet, especially those with conditions like pernicious anemia, certain gastrointestinal disorders, or those taking medications that impact absorption
Funding This research was supported by the National Natural Science Foundation of China (No