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A 2025 meta-analysis pooling several phase 2 randomised controlled trials involving more than 500 participants confirmed these findings, showing 1524% average weight loss across different doses and durations

Adverse event rates reflect aggregate clinical trial and systematic review data

In January 2025, researchers from Medication Weight Loss Clinic, Ireland, found that GLP-1 agonists showed positive results in managing co-occurring obesity and reducing alcohol intake

Effects of glucagon-like peptide 1 (GLP-1) analogs in the hippocampus

A similar program for retatrutide at launch is highly likely

Le Roux CA, Steen O, Lucas KJ, Startseva E, Unseld A, Hennige AM