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As cell mass continues to decrease, the increased metabolic demand, continuous exposure to pro-inflammatory cytokines, and sustained hyperglycemic conditions upregulate mitochondrial and ER stress in cells, which further impair cell function and promote stress-mediated stress (179188)

A better strategy is using melatonin during the initial weeks while Epitalon takes effect, then tapering off the supplement as natural production increases

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Cassier-Chauvat C, Marceau F, Farci S, Ouchane S, Chauvat F (2023) The glutathione system: a journey from cyanobacteria to higher eukaryotes