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AMPK also inhibits lipid biosynthesis by suppressing transcription factor sterol regulatory element-binding protein 1 (SREBP1) and promoting the action of peroxisome proliferator-activated receptor alpha (PPAR), a nuclear receptor that acts to enhance both mitochondrial and peroxisomal FA -oxidation 23

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Alsallaq, R

Despite scarce data in relation to oxidative damage in children suffering from konzo, the role of oxidative damage in many other neurologic diseases has been well established 37

It may be related to the dose of the toxic drug used or the period of study observation.However, most of the current research results support the antioxidant stress effect of GPX1, so GPX1 is an important antioxidant in mammals

It may neutralise free radicals that cause oxidative stress and skin damage