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Metformin, an AMP-activated protein kinase (AMPK) activator widely used in diabetes, is currently in phase I clinical trials for heart failure with preserved ejection fraction (HFpEF) (Tables 1 and 2)

GHK-Cu has demonstrated antioxidant and anti-inflammatory properties in skin models, potentially helping to protect follicles from everyday stressors

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By combining these components, GLOW provides a consistent platform to investigate collagen-related signaling, soft-tissue remodeling, and inflammation-balance pathways in preclinical and in-vitro models