Although the absolute amount of prolactin secreted by adipose tissue is significantly lower than that produced by the anterior pituitary gland, the large number of adipocytes (especially in highly obese individuals) suggests that adipose-derived prolactin may significantly contribute to systemic prolactin production ( de novo , with its expression and secretion strongly stimulated by cyclic adenosine monophosphate (cAMP) enhancers (65)
The superoxide radical, if not scavenged effectively, may directly inactivate several enzymes like CAT and GPx which are needed to eliminate hydrogen peroxide from intracellular medium [83]
The long-term consequence isnt serious pathology your body will eventually restore glutathione balance once weight stabilizes but the subjective experience of losing 1520% body weight becomes more difficult without adequate antioxidant support
Novakova L, Zetterberg H, Sundstrm P, et al
doi: 10.1038/nature15756
Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases, Nitrofurantoin
