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For UA conjugated metabolites, glucuronidation enhances the molecules hydrophilicity, promoting renal excretion, whereas sulfation may attenuate the biological activity of the UA monomer

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PMID: 152 ZhouY.GilmoreK.RamirezS.SettelsE.GammeltoftK

The findings confirmed the mechanism of action in females, showing a 30% reduction in self-reported hunger and a remarkable 40% reduction in food cravings