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The study highlighted an important finding: At high per-cycle SPPS yields, linear synthesis can outperform fragment-based approaches, delivering higher overall yields, and simpler, more cost efficient manufacturing processes

TNF-, Tumor necrosis factor alpha

FOXO3 also prevents pro-apoptotic BAX translocation to the mitochondria, hence protecting cells from apoptosis 100

Guthrie et al., 2014

To address this limitation, GLP-1 RAs, such as albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, and semaglutide, have been developed as synthetic analogs of GLP-1 that resist DPP-4-mediated degradation

Half-life extension using serum albumin-binding DARPin domains