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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

Itaconate promotes Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) activation and, subsequently, an anti-inflammatory phenotype in macrophages [245]

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