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Researchers found that "MELANOTAN effectively increases the melanin content of skin in those individuals with MC1R variant alleles and therefore, those most in need of photoprotection." [37] Results, released in December 2009, showed that seven of nine patients treated with afamelanotide could tolerate ambient light exposure and had an improve quality of life after 60 days of treatment

Significant results typically emerge by weeks 12-16 as maintenance doses are reached

They help maintain a healthy balance of gut flora

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A higher rate of congestive heart failure events in the MK-677 group of the Adunsky et al