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In addition to modulation in appetite and food intake, body weight reduction from caloric restriction causes a decrease in energy expenditure beyond what is predicted by the change in body mass

Important: The dosages mentioned here are based on published research

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Studied in models involving NNMT activity, NAD+-related biology, and metabolic pathway regulation

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[2] Other medications that lower seizure threshold (including antipsychotics, tramadol, and some antimalarials) may increase risk when combined with bupropion